By Sudarshan K. Malhotra
A part of a sequence which goals to hide contemporary wisdom within the box of neural technology, this quantity discusses such themes as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in constructing mammals; and improvement of the mammalian auditory hindbrain.
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Additional info for Advances in Neural Science, Volume 2 (Advances in Neural Science)
Substance P The culture systems primarily used to study regulatory mechanisms of SP have been sensory, dorsal root, and sympathetic ganglia. Using cultures of sympathetic ganglia prepared from neonatal rat superior cervical ganglion, Hart et al. (1991) have reported increased SP in cultures containing interleukin 113 (IL-1 ~), and this increase appears to be secondary to an increase in mRNA coding for the preprotachykinin precursor of SE Nuclear transcription assays detect an early increase in preprotachykinin-specific nascent transcripts, suggesting that the ultimate effect of 18 SUSAN KENTROTI and ANTONIA VERNADAKIS IL-1 is on transcription itself.
Within the nervous system cell death or, conversely, neuronal survival is regulated by intricate relationships that occur at various cellular levels. Growth factors and neurotransmitters comprise two major classes of endogenous intracellular signals that affect neuronal survival and thus establish the neuroarchitecture (for a review see Mattson, 1988). Neuropeptides represent a third closely related group of endogenous substances that have been most recently shown to influence the survival of developing neurons.
High densities of binding sites have been noted at P1 in a nucleus located in the ventrolateral ventral horn of caudal segments; whereas in the phrenic motor nucleus and in the dorsal horn binding sites are expressed after P8. Of importance, again, is the finding that SP receptors decrease with age. , 1987). As discussed throughout this chapter, culture studies have provided evidence of the cellular localization of neuropeptides and their receptors. Hosli and Hosli (1985) have contributed an extensive amount of information in this field.
Advances in Neural Science, Volume 2 (Advances in Neural Science) by Sudarshan K. Malhotra