Apoptosis Genes - download pdf or read online

By J. W. Wilson, C. Booth, C. S. Potten (auth.), James W. Wilson, Catherine Booth, Christopher S. Potten (eds.)

ISBN-10: 146137412X

ISBN-13: 9781461374121

ISBN-10: 1461552877

ISBN-13: 9781461552871

Apoptosis, or programmed telephone demise, is a typical technique wherein broken or undesirable cells are dismantled in an orderly and atraumatic type. it truly is of severe value in improvement, homeostasis, and telephone inhabitants keep an eye on. learn during the last decade is now allowing scientists to understand how genes and the protein items engage to regulate apoptosis. This has ended in the present place the place researchers are able to without delay regulate the motion of key proteins via gene treatment and antisense oligonucleotides.
Apoptosis Genes provides a present assessment of key genes thinking about the regulate of apoptosis examine including techniques on destiny customers and scientific purposes. whereas there are a number of books written on apoptosis, Apoptosis Genes bargains in particular with the rules of apoptosis. Given the elevated curiosity within the position of apoptosis genes in disorder techniques, this paintings might be necessary to researchers investigating melanoma, autoimmune ailment, viral an infection, heart problems, neurodegenerative problems, AIDS, osteoporosis, and aging.

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Cancer Res. 54: 614-617. , Halevy,O. and Oren,M. (1990) Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant ofp53. Cell 62: 671-680. Miyashita,T. C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299. Moll UM, Riouo G and Levine AJ. (1992) Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc. NaIL. Acad. Sci. USA 89: 7262-7266. , Benard,J. and Riou,G. (1995) Wild-type p53 undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1996b) Role for c·abl tyrosine kinase in growth arrest response to DNA damage. Nature 382: 272-274. , el al. (\ 992) Wild·type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Gen. Dev. 6: 1143-1152. P. J. (1993) A comparison of the biological activities of wild·type and mutant p53. FASEB J. 7: 855-865. Chapter 3 Mammalian bcl-2 family genes Thomas Chittenden Apoptosis Technology Inc, 148 Sidney Street, Cambridge MA 02/39-4239, USA. 0 References 3. 0 INTRODUCTION Research on the molecular action of oncogenes has often yielded important insights into key signal transduction pathways that regulate the growth of cells.

Acad. Sci. USA 91: 8940-8944. Shen,Y. E. (1995) Viruses and apoptosis. Curro Opin. Genet. Dev. 5: 105-111. , et al. (1994) Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266: 1376-1380. , Jacks,T. and Cory,S. (I 994) DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by bcI-2. Cell 79: 329-339. , et al. (1994) p53-dependent apoptosis suppresses tumor growth and progression in vivlJ. Ce1l7S: 703-711.

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Apoptosis Genes by J. W. Wilson, C. Booth, C. S. Potten (auth.), James W. Wilson, Catherine Booth, Christopher S. Potten (eds.)


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